View All Mass Spectrometry at Instruct
HDX Mass Spectrometry gives information of the exchange of hydrogen for deuterium on the protein backbone. Uptake rate is determined by each site’s solvent accessibility. Comparing the extent of deuterium exchange in a ‘apo’-protein with a target (agonist, antagonist, inhibitor, lipid etc) bound protein can provide information about conformational changes, active sites and important binding residues.
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