Postdoctoral Scientist in Structural Biology
Weatherall Institute of Molecular Medicine
University of Oxford
University Grade 7: £29,541 – £36,298 p.a.
Applications are invited for a postdoctoral position to discover and develop inhibitors of oncogenic proteins for cancer treatment. The post is available for 3 years, funded by the Medical Research Council.
The aim of the work is to discover small-molecule drugs that inhibit protein-protein interactions involving transcription factor multi-protein complexes. The approach will involve novels strategies using single domain antibody fragments and peptides as tools for the identification of drug-like molecules for hit to lead development and assay development for characterization and target validation.
The programme involves structural determination of protein complexes together with screening and characterization of small molecule inhibitors of protein-protein interactions. In particular, the project will use the structure of single antibody domains as templates for drug lead development.
Candidates must have a PhD in structural biology, experience with recombinant protein production purification, with solving structures using X-ray diffraction and analyzing protein interactions using biophysical techniques. Experience with mammalian and yeast culture would be an advantage
Informal enquiries may be made to Professor Terry Rabbitts at firstname.lastname@example.org
Applications for this vacancy are to be made online. You will be required to upload a CV and supporting statement as part of your online application.
To apply for this role and for further details, including a job description and selection criteria, please click on the link below:-
The closing date for this position is noon on Thursday 21 November 2013.
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