The Jinek laboratory at the University of Zurich, Switzerland, is looking for a talented, goal-driven and team-oriented postdoctoral researcher with a strong background in single-particle cryoelectron microscopy. Research in the Jinek laboratory is focused on studying the molecular structures and mechanisms of CRISPR-Cas and related bacterial defence systems, as well as eukaryotic mRNA processing machineries by cryo-EM. These biological questions are investigated using an integrative approach combining structural biology (X-ray crystallography and increasingly cryo-EM), biochemical and biophysical experiments, and functional studies in cell-based models. As of January 2020, the Jinek lab has regular access to a brand-new FEI Titan Krios (equipped with a K3 camera) in the Department of Biochemistry at the University of Zurich.
The postdoctoral researcher will manage and conduct their independent research project within the main research focus areas of the host laboratory. The researcher is also expected to contribute expertise in single-particle cryo-EM in support of ongoing collaborative projects in the laboratory, closely interacting with PhD students and other postdocs in the group. The laboratory has several exciting projects that would also provide excellent training opportunities in complementary structural biology approaches such as X-ray crystallography or biochemical studies.
Interested candidates should have hands-on experience in cryo-EM sample preparation and expertise in processing single-particle data. Experience with biochemical methods, especially protein expression and purification in bacteria and insect cells would be an advantage.
The position offers a competitive employment package, a supportive and highly collaborative working environment, excellent research funding and state-of-the art infrastructure. Zurich is a major European research hub that also offers an exceptionally high quality of life.
Applicants must hold a PhD in biochemistry or structural biology, and have a strong research track record. Please send your cover letter and a CV, along with contact details of two referees, to Martin Jinek (firstname.lastname@example.org).
Deadline for applications is 31 May 2020.