A 2-year post-doctoral position, funded by the Agence National de la Recherche (ANR), is available in the group of Dr. Laurent Terradot in the Unit Molecular Microbiology and Structural Biochemistry (MMSB) of the Institut de Biologie et Chimie des Protéines (IBCP, CNRS-University of Lyon), Lyon, France.
The group is interested in structure function of protein-protein complexes involved in Helicobacter pylori pathogenesis. This bacterium is a major human pathogen that can cause human diseases such as ulcers and gastric cancers. The position is dedicated to the understanding of Helicobacter pylori Type IV secretion system by the determination of several protein-protein complexes by X-ray crystallography or Cryo-EM. Preliminary data are already available for several protein samples.
For more information on the project see Koelblen et al., 2017; Bergé and Terradot, 2017; Bergé, Wakmsan and Terradot, 2017, Bats et al., 2018; Zhao et al., 2019.
The IBCP is well equipped for cell biology, molecular biology and biochemistry and Structural Biology, and belongs to a larger campus (Lyon Biopole; Center for Infectiology), giving access to state-of-the-art core facilities in areas. The group has regular access to synchrotron beam time and Cryo-EM. Lyon is a vibrant, historical French city and is a world-excellence center in infectiology.
The working language of the laboratory is English. Enthusiastic and self-motivated individuals, with a strong background in protein purification and Structural biology, are sought. Experience in the study of complexes would be a plus. Knowledge in Macromolecular Crystallography and/or Cryo-EM would be considered an advantage but is not mandatory.
For more information and to apply, click here.