Applications are invited for a highly motivated post-doctoral researcher with expertise in structural biology to join the group of Dr Anne-Marie Krachler at the institute of Microbiology and Infection, University of Birmingham. The position is funded by the BBSRC and is part of an exciting project which aims to study a group of bacterial adhesins which bind host cell membrane lipids. This project will entail structural and biophysical studies of this novel adhesin family and adhesin-ligand complexes, with the aim to utilize them as tools to investigate host cellular lipids and potentially as antimicrobials (adhesion inhibitors).
Candidates must have a PhD in biology, biochemistry, biophysics or a related discipline and experience in all aspects of protein crystallography, from protein expression and purification through crystallisation and structure determination. They should also have an interest in working on structural and mechanistic questions related to host-pathogen interactions. Previous experience in studying protein-ligand interactions is highly desirable and a background in studying lipid-binding proteins would be advantageous.