The laboratory of Dr. Thomas Yoonsang Cho in the Department of Biochemistry and Molecular Biology at Saint Louis University School of Medicine invites a highly motivated and creative postdoctoral fellow who is enthusiastic for the structural and functional characterization of ligand-receptor signaling axes in inflammatory diseases and cancer metastasis. The successful candidate is expected to have strong X-ray crystallography background and will be engaged in the crystal structure determination of protein complexes and the cell biological elucidation of the downstream signaling pathways. As for the cell biological functional studies, we employ a label-free technology called dynamic mass redistribution (Nat Biotechnol 2010 Schroder). Please visit our lab website for more details. Active projects are highly collaborative with medicinal chemists and immunologists for the development of novel agonists and antagonists for promising therapeutic targets.
The laboratory is located in the state of the art Doisy Research Center (DRC) on the medical campus of Saint Louis University. The department has three R-Axis IV++ imaging plate systems for high-resolution X-ray diffraction data collection, crystallization robot, differential scanning calorimeter, isothermal titration calorimeter, dynamic light scattering, metabolomics core facility, and bioinformatics facility (http://biochemweb.slu.edu/index.shtml). In the same building, are animal care facility, flow cytometry research core, animal imaging core, microarray core, research microscopy and confocal core, and the Center for World Health and Medicine, which provides a full range of support for drug discovery programs including design and synthesis of small molecules and their preclinical characterization.