Shifman lab in the Hebrew University of Jerusalem is looking for a postdoctoral scholar in Experimental Protein Engineering. In our lab, we engineer inhibitors of protein-protein interactions starting from natural binding partners as well as from unrelated small protein domains. Such inhibitors could be evolved to selectively target only one family member among hundreds of homologs, making them attractive drug candidates.
Using a combination of computational and directed evolution approaches, we convert the natural low-affinity binding partners into high-affinity and high-specificity binders. In the particular project, we would like to engineer specific inhibitors to various types of Matrix Metalloproteinases, enzymes whose activity is related to various diseases including cancer. These molecules will be later transformed into drug candidates.
We are looking for a highly motivated person with a background in Biophysics or Biochemistry to take over this exciting project. The candidate should have experience with molecular biology and protein expression/purification. Experience in yeast surface display is a plus.
Our lab is located in the Department of Biological Chemistry in the Hebrew University of Jerusalem, Jerusalem, Israel. Please contact Julia Shifman: jshifman@mail.huji.ac.il
