PhD positions in structural biology at the Astbury Centre, University of Leeds
University of Leeds, Leeds, United Kingdom
Application deadline: 21 Jan 2019
We invite applications for two PhD positions in structural cell biology based partly or entirely at the Astbury Centre for Structural Molecular Biology, University of Leeds:
- The structure and function of retinal photoreceptor connecting cilium proteins (Closing date: 7th January 2019)
Defects in these proteins are associated with inherited disorders characterized by blindness and/or kidney failure. This project will investigate the structure and function of these proteins by X-ray crystallography, cryo-EM and super-resolution imaging approaches. This is a BBSRC White Rose DTP project supervised jointly between the Cockburn, Johnson and Ranson labs at the University of Leeds; please see https://www.findaphd.com/phds/project/structural-and-functional-studies-on-proteins-required-for-vision/?p59606 for more details.
- The molecular pathogenesis of KIF5A mutations (Closing date: 21st January 2019)
The microtubule motor KIF5A is involved in long-range axonal transport. KIF5A mutations cause inherited spastic paraplegias. This project will investigate the effects of pathogenic mutations on the structure and function of KIF5A. This is an MRC DiMeN DTP project supervised jointly between the Twelvetrees and De Vos labs at the University of Sheffield and the Cockburn lab at the Univerisity of Leeds; please see https://www.findaphd.com/phds/project/mrc-dimen-doctoral-training-partnership-how-do-neurodegenerative-mutations-in-kinesin-1-alter-its-structure-motility-and-cellular-function/?p103997 for more details.
Information on how to apply can be found in the links above. Please feel free to get in touch (j.j.b.cockburn@leeds.ac.uk) if you wish to discuss further or require any additional details.
