Applications are invited for a full-time PhD student position for a maximum of four years, starting at the earliest on 01.01.2020 in a Biocenter Oulu research project headed by Professor Lari Lehtiö in the Structural and Chemical Biology research unit, Faculty of Biochemistry and Molecular Medicine.
The team focuses on structure, function and selective inhibition of proteins involved in signaling through ADP-ribosylation – a post translational modification affecting protein stability, function and interactions in multiple cellular pathways. They use X-ray crystallography, small angle X-ray scattering, cryoEM and other biophysical techniques to study the structure and function of these, often multidomain proteins. They develop assays suitable for high-throughput screening of inhibitors and use structural information for more rational design to develop specific inhibitors that can be used as chemical probes to study the functions of the proteins and in some cases to validate them as drug targets. Protein X-ray crystallography is their main tool used to understand structure-activity relationships of compounds.
The position is supervised by Professor Lehtiö and is focused on structural and functional characterisation of human ADP-ribosyltransferases (PARPs/ARTDs) as well as in development of small molecule inhibitors for the enzymes as tools and as potential future drug leads.
For more information and to apply, click here.