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Instruct-ERIC has put together a Resource Centre with tools, information and support from Instruct and the wider scientific community, to assist research relating to SARS-CoV-2 and COVID-19. If you have resources that you would like to share, get in touch at comms@instruct-eric.eu.

 

Instruct-ERIC Services

Many Instruct-ERIC services are available via remote access, where samples can be sent for analysis without the need for researchers to travel. Highlighted below are key technologies from our catalogue that are currently available for priority COVID-19 research.

 

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Cryo-Electron Microscopy

A sophisticated technique to obtain quantitative structural information on the atomic scale. Includes electron crystallography, single particle analysis and electron tomography.

X-ray Techniques

Includes a variety of approaches to determine the 3D shape of biomolecules at the atomic level, including diffraction and Bio-SAXS at European synchrotrons. XChem fragment screening also available.

Computational Support

A variety of computing services for bioinformatics, modelling, and image processing for electron microscopy and X-ray crystallography.

Molecular Biophysics

An extensive range of techniques to characterise the structure, function and stability of biological macromolecules, and to obtain kinetic and thermodynamic parameters.

Protein Production

Includes cloning, high throughput expression and purification for the production of challenging proteins.

Magnetic Resonance (NMR)

Used to obtain three-dimensional structural and dynamic information about biomolecules in conditions as close as possible to physiological ones. Solution and solid-state NMR available.

Mass Spectrometry

Used to determine protein identity, abundance, modifications (proteomics), shape and topology (ion mobility), inter-subunit connectivity, and equilibrium dynamics (native MS).

Fragment Screening

A method of identifying small organic molecules (fragments) that bind a biological target (eg protein or nucleic acid). Used to find lead compounds as part of the drug discovery process.

 

 

Resources from the Community

 

Flash Reports

 

Name: Structure of the SARS-CoV-2 spike S1 protein in complex with CR3022 Fab

PDB ID: 6YOR

Release date: 29 April 2020

Method: Electron Microscopy

Facility: STRUBI (Instruct Centre UK)

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Name: Crystal structure of the SARS-CoV-2 receptor binding domain in complex with CR3022 Fab

PDB ID: 6YLA

Release date: 15 April 2020

Method: X-ray diffraction

Facility: Diamond Light Source (Instruct Centre UK)

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Name: SARS-CoV-2 main protease with unliganded active site

PDB ID: 6YB7

Release date: 25 March 2020

Method: X-ray diffraction

Facility: Diamond Light Source (Instruct Centre UK)

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Special Features