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Instruct-ERIC has put together a Resource Centre with tools, information and support from Instruct and the wider scientific community, to assist research relating to SARS-CoV-2 and COVID-19. If you have resources that you would like to share, get in touch at firstname.lastname@example.org.
A sophisticated technique to obtain quantitative structural information on the atomic scale. Includes electron crystallography, single particle analysis and electron tomography.
Includes a variety of approaches to determine the 3D shape of biomolecules at the atomic level, including diffraction and Bio-SAXS at European synchrotrons. XChem fragment screening also available.
A variety of computing services for bioinformatics, modelling, and image processing for electron microscopy and X-ray crystallography.
An extensive range of techniques to characterise the structure, function and stability of biological macromolecules, and to obtain kinetic and thermodynamic parameters.
Includes cloning, high throughput expression and purification for the production of challenging proteins.
Magnetic Resonance (NMR)
Used to obtain three-dimensional structural and dynamic information about biomolecules in conditions as close as possible to physiological ones. Solution and solid-state NMR available.
Used to determine protein identity, abundance, modifications (proteomics), shape and topology (ion mobility), inter-subunit connectivity, and equilibrium dynamics (native MS).
A method of identifying small organic molecules (fragments) that bind a biological target (eg protein or nucleic acid). Used to find lead compounds as part of the drug discovery process.