Service / Technology Type

Crystal Form Discovery

Techniques for finding new crystal forms

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Details

For structural work on any given protein, having access to multiple crystal forms is extremely powerful; for example, different crystal forms can show different conformational states, and structure support for lead optimisation requires a packing arrangement that allows ligands to bind.

Once a protein or protein construct is known to crystallize, multiple approaches can be applied to modulate the sample, including surface mutation, changing construct length, chemical modification of surface residues, or extensive exploration of crystallization chemistry.

Service/Technology Instances

Crystal Form Discovery

Crystal Form Discovery Experts

Frank von Delft
Frank von Delft
Department of Biochemistry, University of Oxford
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