Instruct Biennial

Structural Biology Conference

Structural Biology: Deeper into the Cell

22nd - 24th May, 2019

Alcalá de Henares, Madrid, Spain

The 4th Instruct Biennial Structural Biology Conference will take place in Alcalá de Henares, Spain, from May 22 till May 24, 2019. The historical Alcalá de Henares was the original location of the Universidad Complutense, founded in 1293 and one of the oldest universities in the world, as well as being the birthplace of Miguel de Cervantes. The social programme of the meeting will include a visit to the city, a gala dinner and extensive opportunities to network with the Instruct Structural Biology community.

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Helen Saibil

Birkbeck University of London

Julia Mahamid

European Molecular Biology Laboratory

Sjors Scheres

MRC Laboratory of Molecular Biology

Poul Nissen

Aarhus University

Eva Pereiro

ALBA Synchrotron

Teresa Carlomagno

Leibniz University Hannover

Andy Dore


Hashim M Al-Hashimi

Duke University

Andrej Sali

University of California

Dave Stuart

Instruct-ERIC, University of Oxford

Dorit Hanein

Institut Pasteur

Brent Nannenga

Arizona State University

Patrick England

Institut Pasteur

Ilaria Ferlenghi

GSK Vaccines

Alex De Marco

Monash University

Bohdan Schneider

Institute of Biotechnology of the Czech Academy of Sciences

Moran Shalev-Benami

Weizmann Institute

Guillermo Montoya


Ana Cuervo


Rubén Fernández-Busnadiego

Max Planck Institute of Biochemistry

Instruct is a distributed European Research Infrastructure, which provides scientists with access to all major cutting edge technologies that enable biomacromolecular structure determination at atomic resolution. Access to all of these technologies has been available to European member researchers from February 2012.

The inaugural Instruct Structural Biology Meeting at Heidelberg in 2013 successfully showcased integrative structural biology and its impact on biological research and biomedicine. The second Biennial took place in Florence in 2015 continuing the integrative line with an increased focus on innovation. The last edition which took place in Brno in the Czech Republic included sessions representing recent structural biology highlights, emerging methods and technologies and results of biomedical importance. We have already confirmed outstanding speakers for this 4th edition and we are looking forward to see you there.

Registration Fees:

€65 for participants from Instruct Countries

€450 for participants from non-Instruct Countries

This will cover attendance, coffee breaks, lunch and conference gala. There will be additional costs for accommodation.

Abstract Submission Deadlines:

Abstract submission: March 1st 2019 | Registration closed: April 1st 2019 | Student fellowship: March 1st 2019

Abstract submissions from registered applicants will be selected for poster presentations and four abstracts will be selected for oral presentation. The poster size should be A0 and in portrait orientation.

Organising Committee

Download Abstract Booklet

Abstracts Booklet.pdf

Download Event Programme

Biennial Programme.pdf

Download Speaker's Presentations

Biennial Programme.pdf

The Spanish National Bioinformatics Institute (INB) is the ISCIII Bioinformatics platform. Its Coordination Node is supported by grant PT17/0009/0001, of the Acción Estratégica en Salud 2013-2016 of the Programa Estatal de Investigación Orientada a los Retos de la Sociedad, funded by the Instituto de Salud Carlos III (ISCIII) and European Regional Development Fund (ERDF)

Day 1 - Wednesday 22nd May

Satellite Events

Instruct-Ultra General Assembly

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13:00 - 15:30
22nd May

Women in Science Workshop

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16:00 - 19:00
22nd May

Instruct-ERIC Manager Workshop

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13:00 - 15:30
22nd May

Computational Working Group

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20:00 - 21:00
22nd May

Day 2 - Thursday 23rd May

09:00-09:15Prof. Rafael Rodrigo Montero (Secretario General de Coordinación de Política Científica, Ministerio de Ciencia, Innovación y Universidades)Inauguration of the Biennial Conference and official welcome to Spain as a member of Instruct-ERIC

Session 1: Structural Biology towards Cellular Biology - Integrating Biology

(Chairs: Margarida Archer, Vladimir Sklenar)

09:15-09:40Helen Saibil (Birkbeck University of London)Takeover and destruction of red blood cells by malaria parasites
09:45-10:10Julia Mahamid (EMBL Heidleberg)Molecular Views into Cellular Function by in situ Cryo-Electron Tomography
10:15-10:40Dorit Hanein (Institut Pasteur)Unravelling cancer cell nanoarchitecture through multiscale imaging; Coupling molecular activation, biosensors and their functional output
11:00-11:20Moran Shalev-Benami (Weizmann Institute)Deadly Spiders & Scary Zombies - NOT a Halloween Story - A near atomic resolution glance into the CNS
11:20-11:45Ilaria Ferlenghi (GSK)GEMINI: an integrated structural approach for vaccine identification and pathogenesis insight
11:45-12:00Presentation of the Ivano Bertini award by Bruker and Lucia Banci
12:00-12:25Ivano Bertini Award talk: Professor Wolfgang Baumeister
Lunch and ThermoFisher talk - Engaging in Cryo-EM (13:00 - 13:30)

Session 2: Structural Biology and Health - Current Challenges

(Chairs: Helen Saibil, Wolfgang Baumeister)

14:00-14:25Andy Dore (Heptares)Structural insights into the allosteric control of GPCR activity
14:30-14:55Sjors Scheres (MRC)Structures of tau filaments extracted from the brains of individuals with Alzheimer's and Pick's disease
15:00-15:20Guillermo Montoya (NNF-CPR)Cryo-EM analysis unveils the conformational activation of CRISPR-Cas12a and the endonuclease activity resetting
15:50-16:15Poul Nissen (Aarhus University)Structure and Dynamics of Membrane Transport Proteins
16:20-16:40Ana Cuervo (CNB-CSIC)Snapshots of T7 viral connector and tail machinery structures suggest a model for DNA retention inside the capsid
16:40-17:00Rubén Fernández-Busnadiego (Max Planck Institute of Biochemistry)Unravelling the structure of toxic protein aggregates in situ
17:00-18:00Poster session & Drinks (Even number posters)Abstract Booklet Download
18:00-19:00Poster session & Drinks (Odd number posters)
19:00-20:00Satellite Meeting - Spanish Structural Biology Community
20:00Conference Gala

Day 3 - Friday 24th May

Session 3: Emerging Technologies in Integrative Structural Biology

(Chairs: Dave Stuart, Jose Maria Carazo)

09:00-09:25Andrej Sali (UCSF)Integrative Structural Biology
09:30-09:55Hashim M Al-Hashimi (Duke University)Visualizing the invisible genome: Fleeting structures of DNA in gene expression and genome stability
10:00-10:25Eva Pereiro (Synchrotron ALBA)Correlative X-ray imaging of cells
11:00-11:20Bohdan Schneider (Institute of Biotechnology of the Czech Academy of Sciences)3D-Bioinfo: ELIXIR Community of Structural Bioinformatics
11:25-11:50Patrick England (Institut Pasteur)Molecular-scale biophysics methods for sample quality control and quantitative characterisation
12:00-12:25Teresa Carlomagno (Leibniz University Hannover)Studying multicomponent complexes by integrative structural biology
12:30-12:40Group photo
Lunch and talk by European Network of FT-ICR Research Centers: An Extreme Resolution Mass Spectrometry and Structural Biology Resource for Europe

Session 4: New Trends

(Chairs: Anastassis Perrakis and Thomas Vosegaard)

14:00-14:25Brent Nannenga (Arizona State University)Structure determination by microcrystal electron diffraction
14:30-14:55Alex De Marco (Monash University)Increasing the Throughput cryo EM sample preparation
15:00-15:30Dave Stuart (University of Oxford)Research Infrastructures in the changing landscape of Structural Biology
15:30-16:00Poster prize presentation and closing address


Getting to Alcalá de Henares

From the airport (Barajas Madrid international airport) by bus:

There is a direct bus from the airport to Alcalá de Henares, number 824. The timetable is available here. The journey time is approximately 50 minutes.

From the airport by taxi:

You can also take a taxi from the airport to your hotel in Alcalá. The journey time is approximately 30 minutes.

From the airport using subway and train:

A train to Alcalá de Henares can be taken at Nuevos Ministerios or Chamartin station.

From Nuevos Ministerios: To go there, you must first take the subway (“Metro”) at the airport. It is located in the middle of Terminal T2 (corridor connecting to Parking P2, 1st floor). The subway station is called Aeropuerto. You can find it on the map here.

Nuevos Ministerios is also a train station, where you must take the RENFE urban train (“CERCANÍAS”) to Alcalá de Henares. There are three lines connecting Nuevos Ministerios with Alcalá de Henares (lines C-1, C-2 and C-7). More information is available from the RENFE website. The journey from the airport to Alcala de Henares should take approximately 60-75 minutes.

From Chamartin station:

Line C1: Príncipe Pío - Atocha - Recoletos - Chamartín - T4 Airport

Line C1 of Renfe Cercanías runs from terminal T4 of Adolfo Suárez Madrid-Barajas airport to the city centre.

At Chamartin station you must take the RENFE urban train (“CERCANÍAS”) to Alcalá de Henares. There are three lines connecting Chamartin with Alcalá de Henares (lines C-1, C-2 and C-7).

More info at:

Venue: Parador de Alcalá

17th-century monastery school and student lodgings located in the former San Jerónimo College centrally located in this world heritage city.

Dirección: Colegios, 8 28801 Alcalá de Henares Madrid+34 918880330 +34 918880527

We have had reports of phishing attempts relating to accommodation bookings. If you're unsure of any email communications, please contact us.


Student Fellowships

Student Fellowship applications are invited from graduate students.

Fellowships will cover economy travel costs plus shared accommodation (twin room) for 2 nights.

  • Applicants should be pre-doctoral scientists (PhD students).
  • The applicant’s home institution (applicant’s usual workplace) must be within an Instruct Member country.
  • Recipients must submit a 500 word short report on their conference experience by 1st June 2019.

Applicants should send a copy of the abstract submitted upon registration and a 200 word statement justifying their application and a letter of recommendation from their supervisor to

The deadline for Fellowship applications is 1st March 2019.

Women in Science Fellowships

Instruct-ULTRA is sponsoring four fellowships for women scientists to attend the Women in Science (WIS) Workshop and stay on for the Biennial conference.

Fellowships will cover economy travel plus shared accommodation for 2 nights (twin room).

  • Women applicants can be at any stage of their scientific career.
  • Applicants can be from any European country or Instruct associated member country.
  • Recipients must submit a 500 word short report on their conference experience prior to reimbursement.

Applicants should send a 200 word statement justifying their motivation to attend the workshop and the Instruct Biennial Conference and a letter of recommendation from their supervisor/employer/director to Those applicants that will submit an abstract upon registration should also send a copy of the abstract at the same address.

Facility managers, research technicians, project managers and communication officers are also encouraged to apply.

The deadline for WIS fellowship applications is 1st March 2019.

Ivano Bertini Award

The Ivano Bertini Award recognises a significant achievement in frontier research that utilises an integrative structural biology approach. The first recipient of the award was Stephen Cusack FRS, Head of EMBL Outstation in Grenoble. His work on the structure of protein-RNA complexes and proteins involved in host-pathogen responses is ground-breaking and exemplifies the power of using integrated technology approaches in research.

The Award is the first commemorating Ivano Bertini who developed powerful new methods in NMR and built up a world class Centre for Magnetic Resonance (CERM) in Florence. CERM was in the first group of major Centres in structural biology to form the core structure of Instruct.

The Award of €15,000 is endowed by Bruker BioSpin which, together with Ivano, developed NMR instrumentation to broaden its application and increase measurement sensitivity.

Applications are now closed.

Confidentiality Policy

Confidentiality and Use of Information

All material presented at the IBSBC2019, including abstracts, oral presentations and posters, must be treated as personal communication and should be cited only with the consent of the author.

Photography or video/audio recording of oral presentations or individual posters is strictly prohibited unless with explicit consent of the meeting organisers and the author.

The content of abstracts, oral and poster presentations are the responsibility of the author(s). Instruct will publish the content of the submitted abstracts without asking for explicit consent from the author(s).

Social Media

We encourage participants to blog, tweet or otherwise communicate about the meeting (#IBSBC2019). However, dissemination of results or discussion presented at the meeting to anonymous third parties must obtain permission from the presenting author BEFORE communicating any results or discussion to third party groups, message boards, blogs or other online resources (other than your own lab or departments).

If you have specific questions regarding these issues or any other aspects of the conference, please contact the IBSBC2019 organising team. Send a message to or call us at +44 1865 98 86 39 to speak with one of our team.