Instruct-ERIC webinar series: structure meets function

 

Featuring expert speakers from Instruct Centres across Europe, this webinar series highlights some of the latest developments in structural biology, demonstrating how integrative methods are enabling scientists to decipher the mechanisms that underpin health and disease.

 

Webinar #32 IBS Grenoble | 19 March 2024

Moderator: Marylène Vandevenne, Robotein

Speaker 1: Nikitas Georgiou - National and Kapodistrian University of Athens

Speaker 2: Séverine Padiolleau - Université de Technologie de Compiègne

 

 

 

Webinar #31 IBS Grenoble | 19 March 2024

Moderator: Martin Blackledge, IBS Grenoble

Speaker 1: Vincent Chaptal, IBCP Lyon

Speaker 2: Barbara Zambelli, University of Bologna

 

 

 

 

Webinar #30 AI and Machine Learning | 13 February 2024

Speaker 1: Beatriz Serrano-Solano, AI4Life

Speaker 2: Tiago Rodrigues, FF Ulisboa

Speaker 3: Enara Vijil, IBM

 

 

Webinar #29 Instruct-FR1 | 23 January 2024

Speaker 1: Katia Zanier - Université de Strasbourg
Title: Mechanism of IKK kinase-substrate docking in NF-kB signaling

Speaker 2: Konstantin Brodolin - Université de Montpellier
Title: Regulation of transcription via RNA polymerase oligomerization

 

 

 

Webinar #28 Instruct-FI | 17 October 2023

Moderator: Janne Janis, University of Eastern Finland

Talk 1: Ilona Rissanen, University of Helsinki
Title: Structure meets potency: Insights into effective SARS-CoV-2 inhibition

Talk 2: Giovanna Viola, University of Verona
Title: Investigating the influence of ubiquitination on the conformational propensities of the amyloidogenic Tau protein by mass spectrometry methods

 

Webinar #27 Instruct-BE and EMBL | 13 June 2023

Moderator: Maria Garcia, EMBL

Talk 1: Daphnée Georges, ULB & ULiège, BE
Title: High throughput assay for IgG avidity determination in the context of SARS-CoV-2 infection and/or vaccination

Talk 2: Maria Dimarogona, University of Patras, GR
Title: Structural insights into carbohydrate-active enzymes for the design of plastic degrading biocatalysts

Talk 3: Leonardo Alonso, University of Buenos Aires, AR
Title: Behind the functional role of asparagine deamidation in coronavirus proteins

Register for the Webinar here.

 

Webinar #26 New Instruct Technologies | 16 May 2023

Speaker 1: Javier Conesa

Speaker 2: David Herreros

Talk Title: Introduction to CNB-CSIC CLEM, and I2PC FlexiHub.

Speaker 3: Alexandre Durand

Speaker 4: Catherine Birck

Talk Title: Introduction to IGBMC Chameleon and BLI/FIDA.

 

 

Webinar #25 Instruct-CZ Users | 14 March 2023

 

Moderator: Jan Dohnalek

Speaker: Tibor Fuzik

Talk Title: Structure of tick-borne encephalitis virus immature particle solved by cryo-electron microscopy and sub-tomogram averaging

Speaker: Ondrej Vanek

Talk Title: Structure of the human NK cell NKR-P1:LLT1 receptor:ligand complex reveals clustering in the immune synapse

 

Webinar #24 Special Edition: Instruct Access Provision | 14 February 2023

 

Moderator: Josan Marquez

Speaker: Simone Di Micco, EBRIS

Talk Title: Design and structural insights of new zonulin inhibitor Larazotide (AT1001) derivatives as potential anti SARS-CoV-2.

Speaker: Felipe Trajtenberg, IP Montevideo

Talk Title: Allostery in bacterial two-component signaling systems: building efficient information processing machines

Speaker: Alejandro Buschiazzo, IP Montevideo

Talk Title: An asymmetric structure of the filament is key to inducing flagellar curvature and enabling motility in the Leptospira spirochete

 

Webinar #23 Special Edition: Instruct partner in Latin America | 13 December 2022

 

Moderator Ana Zeri

Speaker: Leticia Llarrull, IBR-CONICET

Talk Title: Advances in structural and functional characterization of the sensor/transducer MecR1 protein of Staphylococcus aureus

Speaker: Alejandro Vila, IBR-CONICET

Talk Title: In-cell kinetic stability is an essential trait in protein evolution: the case of Metallo-beta-lactamases

Register and join the webinar here.

 

Webinar #22 Special Edition: Instruct partner in Latin America | 12 October 2022

 

Moderator Natalia Lisa

Speaker: Richard Garratt, University of Sao Paulo

Talk Title: Protein crystallography off the beaten track: Septins, their filaments and the importance of access to research infrastructure

Speaker: Italo Cavini, University of Sao Paulo

Talk Title: The versatile septin coiled-coil domains

 

Webinar #21 Special Edition | 6 September 2022

 

Moderator Rolf Boelens

Speaker: Markus Weingarth, Bijvoet Centre, Utrecht University

Talk Title: Teixobactin kills bacteria by a two-pronged attack on the cell envelope

 

Webinar #20 Instruct UK - 7 June 2022

 

Talk 1: Understanding the mechanism of the bifurcating hydrogenase from Thermotoga maritima through the application of cryoEM and symmetry expansion

Speaker: Jamie Blaza, Universiti of York

Talk 2: Structure and mechanism of action of Vip3 toxins

Speaker: Colin Berry, Cardiff University

 

Webinar #19 Instruct Spain - 10 May 2022

 

Talk 1: Characterisation of the Chikungunya virus nsP1 RNA capping pathway using the cryoEM facilities at Instruct CNB

Speaker: Rhian Jones

Talk 2: From Structure to Function and Back - identifying a medically crucial membrane protein by CryoEM

Speaker: Simone Weyand

Talk 3: Visualizing key regulatory allosteric mechanisms in bacterial glycogen biosynthesis

Speaker: Javier Cifuente

 

Webinar #18 Instruct Netherlands - 12 April 2022

Duration: 1 hour 30 minutes

Talk 1: A Real-Time Approach to Study Cellular Metabolism in Hepatocytes
Speaker: Simone Fjordside

Talk 2: Reconstituting the 2D world of signalling proteins – exploring the role of membrane topography for information transfer
Speaker: Kristina Ganzinger

Talk 3: Structure of a proteo-lipidic viral tail-tube for viral genome delivery
Speaker: Nicola Abrescia

 

Webinar #17 Instruct Italy - 15 March 2022

Duration: 1 hour

Talk 1: Characterization of the intrinsically disordered region of human N-myc downstream regulated gene-1, a possible target for lung cancer therapy
Speaker: Barbara Zambelli

Talk 2: Novel interaction between the key mitochondrial oxidoreductase Mia40 and the major thiol peroxidase Gpx3
Speaker: Kostas Tokatlidis

 

Webinar #16 Instruct Israel - 8 Feb 2022

Duration: 1 hour

Talk 1: SARS-CoV-2 Omicron prediction and antiviral drug design are enabled by RBD in vitro evolution
Speaker: Gideon Schreiber

Talk 2: AlphaFold and protein optimisation
Speaker: Shiran Barber-Zucker

 

Webinar #15 Instruct Portugal - 14 Dec 2021

Video Duration: 1 hour
Webinar Moderator: Maria Arménia Carrondo, Universidade Nova de Lisboa

Talk 1: Exploring a new drug target against Mycobacterium tuberculosis
Speaker: Hugo Fraga

Talk 2: Breaking the limits of native MS with MRMS
Speaker: Carlos Cordeiro

Talk 3: Catching up with the CryoEM Resolution Revolution
Speaker: Pedro Matias

 

Webinar #14 Instruct Lithuania - 16 Nov 2021

Duration: 1 hour 13 minutes

Talk 1: Biomembranes on a chip: tethered phospholipid bilayers for protein membrane interaction studies
Speaker: Gintaras Valinčius

Talk 2: Bacterial immunity: from restriction enzymes to CRISPR
Speaker: Virginijus Šikšnys

 

Webinar #13 Instruct Slovakia - 12 Oct 2021

Duration: 1 hour 06 minutes

Talk 1: Interpreting Single-Molecule Force Spectroscopy Experiments with Normal Mode Analysis
Speaker: Jacob Bauer

Talk 2: Mass Spectrometry in Glycoproteomic Analyses
Speaker: Zuzana Pakanová

Talk 3: Development of single-molecule protein biophysics
Speaker: Gabriel Žoldák

 

Webinar #12 Instruct Latvia - 14 Sept 2021

Duration: 1 hour 20 minutes

Talk 1: ssRNA phages – structural studies and applications of their virus-like particles
Speaker: Kaspars Tars

Talk 2: Structural and functional insights into GRM2 type choline degrading type bacterial microcompartments
Speaker: Gints Kalnins

Talk 3: Spider silk: from NMR structural studies to mechanism of formation and artificial fibres
Speaker: Kristaps Jaudzems

 

Webinar #11 Instruct Centre FR2 - 08 June 2021

Duration: 1 hour 12 minutes

Talk 1: DC-SIGN and L-SIGN receptors from immune cells recognize spike glycoprotein and promote SARS CoV-2 trans infection
Speaker: Franck Fieschi

Talk 2: Photoenzyme at work: Structural dynamics of fatty acid photodecarboxylase
Speaker: Martin Weik

Talk 3: The high resolution cryo-EM structure of full-length La Crosse virus polymerase reveals functionally important conformational changes
Speaker: Helene Malet

 

Webinar #10 Instruct Centre FR1 - 12 May 2021

Duration: 1 hour 21 minutes

Talk 1: Structural basis for the allosteric regulation of Human Topoisomerase 2α
Speaker: Valérie Lamour

Talk 2: Structure of the SAGA transcriptional co-activator
Speaker: Gabor Papai

Talk 3: Structural basis of transcription translation coupling and collision in bacteria
Speaker: Albert Weixlbaumer

 

 

Webinar #9 Instruct Centre FI - 13 April 2021

Duration: 1 hour 13 minutes

Talk 1: Biocomplex: Sample preparation strategies for biomolecular complexes
Speaker: Minna Poranen

Talk 2: Switching on ADP-ribosylation at the DNA damage site
Speaker: Lari Lehtiö

Talk 3: High-resolution native mass spectrometry as a versatile tool in structural biology
Speaker: Juha Rouvinen

 

Webinar #8 Instruct Centre EMBL - 16 March 2021

Duration: 1 hour 18 minutes

Talk 1: In-situ structural analysis of SARS-CoV-2 spike protein using subtomogram averaging and molecular dynamics
Speaker: Beata Turonova

Talk 2: Structural analysis of COVID-19-related molecules at EMBL Hamburg
Speaker: Dmitri Svergun

Talk 3: Online crystallography: Automated pipelines for protein crystallography and drug design
Speaker: Jose A. Marquez

 

Webinar #7 Instruct Centre CZ - 17 February 2021

Duration: 1 hour 18 minutes

Talk 1: Enterovirus genome release and delivery
Speaker: Pavel Plevka

Talk 2: Sweeping RNA polymerase - role of protein HelD in bacterial transcription
Speaker: Jan Dohnálek

Talk 3: Probing structures and interactions of nucleic acids in living human cells using NMR Spectroscopy
Speaker: Lukáš Trantírek

 

Webinar #6 Instruct Centre BE - 12 January 2021

Duration: 1 hour 35 minutes

Talk 1: Curli – structure, function and application of a bacterial amyloid pathway
Speaker: Han Remaut

Talk 2: Protein formulation through automated screening of pH and buffer conditions using the Robotein® high throughput facility
Speaker: Andre Matagne

 

Webinar #5 Instruct Centre UK - 15 December 2020

 

Webinar #4 Instruct Centre Spain - 10 November 2020

Duration: 1 hour 9 minutes

Talk 1: Beyond static structural models: Analysis of continuous protein flexibility by Cryo-EM and its application to SARS-CoV-2
Speaker: José María Carazo and Marta Martinez

Talk 2: An image processing pipeline for SARS-CoV-2 Cryo-EM: a single method is not enough
Speaker: Carlos Óscar Sánchez Sorzano

Talk 3: Integrating structural information and biomedical annotations: 3DBionotes-Covid19 Portal
Speaker: José Ramón Macías

 

Webinar #3 Instruct Centre Netherlands - 13 October 2020

Duration: 1 hour 16 minutes

Talk 1: Protein structure and interactions control contacts in the nervous system
Speaker: Bert Janssen

Talk 2: High-resolution NMR of antibiotics in the native state
Speaker: Markus Weingarth

Talk 3: Cryo-EM structures reveal the selection process for DNA mismatch repair initiation
Speaker: Meindert Lamers

 

Webinar #2 Instruct Centre Italy - 18 September 2020

Duration: 1 hour 9 minutes

Talk 1: Drug screening by in-cell NMR
Speaker: Enrico Luchinat

Talk 2: 1.2 GHz NMR applied to Sars-CoV2 proteins
Speaker: Francesca Cantini

Talk 3: SS NMR of functionalised biomaterials
Speaker: Marco Fragai

 

Webinar #1 Instruct Centre Israel - 18 August 2020

Duration: 1 hour 6 minutes

Talk 1: Crowdsourcing for SARS-CoV-2 Mpro inhibitor - a global effort driven by structural biology
Speaker: Dr Nir London

Talk 2: Line-FRAP, a method to measure diffusion rates of a large range of molecules in vitro and in vivo
Speaker: Prof Gideon Schreiber