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Native mass spectrometry allows the structural investigation of protein complexes. It does not provide a structural model in atomic detail, but the sensitivity, speed, selectivity, unlimited mass range and accuracy of the analysis provides important advantages over other techniques. It’s sensitivity allows the investigation of endogenous protein complexes. For native MS, the Biomolecular Mass Spectrometry and Proteomics group at the Bijvoet Centre has LCT mass spectrometers for the analysis of peptides, unfolded proteins and native proteins and protein complexes and modified Q-ToF mass spectrometers for structural analysis proteins and protein complexes.
Native mass spectrometry allows the structural investigation of protein complexes. It will not provide a structural model in atomic detail, but the sensitivity, speed, selectivity, unlimited mass range and accuracy of the analysis provides important advantages over other techniques. It’s sensitivity allows the investigation of endogenous protein complexes. For native MS, the Biomolecular Mass Spectrometry and Proteomics group at the Bijvoet Center has LCT mass spectrometers for the analysis of peptides, unfolded proteins and native proteins and protein complexes and modified Q-ToF mass spectrometers for structural analysis proteins and protein complexes.
Please see the research group website for more information.