Two postdoctoral positions are available in the laboratory of Dr. Pengxiang Huang, Assistant Professor and CPRIT scholar in cancer research in the Department of Molecular and Cellular Biology at Baylor College of Medicine. With the long-standing interest in sterol lipids, the Huang lab investigates the poorly understood mechanisms involved in Hedgehog (Hh) and Wnt signal transduction, two related pathways that play critical roles in development, regeneration and cancer.
They utilize a combination of biochemistry, cell, chemical and structural biology approaches, including both X-ray crystallography and Cryo-EM. Their recent work identified cholesterol as the endogenous ligand for Smoothened, the key signal transduer and oncoprotein in the Hh pathway (Cell. 166:1176-87). They also characterized the structural and oncogenic basis of Smoothened activation, demonstrating for the first time the active conformation of a class F GPCR (Cell. 174:312-24). The highly interdisciplinary and collaborative environment of our group will thus provide unique career development opportunities for future postdoctoral trainees.
They are seeking highly-motivated candidates with a Ph.D. in biomedical sciences and significant experience in molecular biology, protein biochemistry and/or cell biology. Prior knowledge in structural biology (X-ray crystallography or Cryo-EM) is highly desirable, but not required. Candidates should have a documented publication record in peer-reviewed journals, able to work both independently and as an effective team member.
To apply, please send your CV, a short summary of research experience, and three reference letters to cnssolve[at]gmail.com.
