Jobs in Structural Biology and Related Fields


Research Associate focused on bacterial secretion systems, Imperial College London


Imperial College London, London, United Kingdom
Application deadline: 24 Jun 2019


Overview

A Research Associate position is available for three outstanding structural biologists to join the group of Dr Harry Low, Department of Life Sciences. The research project focuses on determining the molecular mechanism of bacterial secretion systems including the type 2 secretion system and other significant macromolecular membrane complexes. Methodology will include cryo-electron microscopy (EM) and a suite of biophysical, biochemical and cellular assays to determine structure and function. The positions are funded by the Wellcome Trust.

 

Duties and responsibilities

You will be expected to take a leading role in studying the bacterial type 2 secretion system and other macromolecular complexes such as the type 4 pilus system. Structure and functional studies will be undertaken with an emphasis on taking advantage of the recent resolution revolution in cryo-EM. At times, you will mentor junior biochemists/structural biologists in our research team.

 

Essential requirements

You will have a PhD (or equivalent) in structural biology, either cryo-EM, X-ray crystallography or NMR. Experience in cryo-EM and working with membrane complexes is advantageous. Experience in the design and execution of workflow for structure determination of proteins, from molecular biology/biochemical experiments (e.g. DNA cloning and mutagenesis, protein purification) through to structural data collection, analysis and model building is expected. You must have a strong research track record demonstrated by first author publications in international journals.

Excellent verbal and written communication skills, and the ability to write clearly and succinctly for publication is essential. You will relate well with others, form positive relationships with a wide range of people and work as part of a team, as well as independently. The ability to develop and apply new concepts and have a creative approach to problem-solving, to set and attain research objectives in a multidisciplinary team are also essential.

 

For more information and to apply, click here.

London, United Kingdom

Research Associate focused on bacterial secretion systems, Imperial College London