Jobs in Structural Biology and Related Fields

Research Assistant

Vienna, Austria
Application deadline: 14 Mar 2014

Applications are invited for a Research Technical Assistant Position in  Structural Studies on Fcabs, Antibody Fragments with Antigen Binding Properties, at Max.F.Perutz Laboratories.
Monoclonal antibodies (mAbs) are the most successful biologically produced therapeutics  today. They  are applied for the treatment of many different diseases, including cancer, autoimmune diseases, and infectious diseases.  Within the  Christian  Doppler Laboratory for Antibody  Engineering coordinated by Christian Obinger,  new  generations  of  engineered mAbs with improved  properties are being  developed. Constant domains (Fc) of  human IgG1 are engineered by an integrated  set of approaches  to (i)  enhance their stability  and  folding,  and  (ii)  introduce Antigen Binding  sites  by engineering  the non-CDR loops.  Selected  Fcabs  will  be  characterized  by various biophysical  methods  and  their  structures alone  and/or  in  complex  with  selected  antigens determined by X-ray crystallography.
As a Research Technician, you will be involved in protein production, purification, and biophysical characterization, crystallization and structure determination.
Please send your application, including a letter of interest, a detailed CV, and contact details for two references to Kristina Djinovic Carugo.