This is a joint collaborative project between Israel and the University of Hamburg on the "mechanisms governing virulence and antibacterial properties of protein fibrils in infectious and aggregation diseases".
The research methods include single particle cryoEM reconstruction, correlative light and electron microscopy, artificial membrane systems (supported lipid bilayers, liposomes), and live cell microscopy to study toxicity mechanisms of fibrils on bacteria and mammalian cells and within microbial biofilms.
Project leaders are Associate Prof. Meytal Landau, Technion-Israel Institute of Technology; Prof. Dr. rer. nat. Kay Grünewald, Heinrich-Pette-Institute, Leibniz Institute of Experimental Virology and Universität Hamburg, Fakultät für Mathematik, Informatik und Naturwissenschaften (MIN) and Centre for Structural Systems Biology (CSSB), DESY, Hamburg; Dr. Carolin Seuring, Head of the CryoEM Multi-User Facility, CSSB; Dr. Roland Thünauer, Head of the Advanced Light and Fluorescence Microscopy Facility, CSSB.
The research will be conducted at the CSSB on the Bahrenfeld Research Campus, Hamburg, Germany, also the home of the German synchrotron DESY, with occasional visits to Israel. CSSB harbors state-of-the-art multi-user facilities for protein production and characterization, high-throughput crystallization, advanced light microscopy and electron microscopy.
Requirements:
• PhD in the field of structural biology, biophysics, or related fields
• Fluent in English (both written and oral)
• Experience in protein science and structural biology
• Desirable experience in cryo-EM and/or light microscopy
• The ability to work independently and as part of a team
• A high level of motivation
• Self-driven and organised
The position commences as soon as possible and is a fixed-term contract for a period of 2 years.
For applications and further information, please contact Prof. Meytal Landau (mlandau@technion.ac.il) and Prof. Dr. rer. nat. Kay Grünewald (kay.gruenewald@cssb-hamburg.de).
