The Structural Genomics Consortium (SGC) in the Faculty of Medicine, University of Toronto invites applications for the Postdoctoral position (Limited Term) to join the SGC’s structural biology team to investigate the structure, mechanism and druggability of human WD-repeat (WDR) domain containing proteins using X-ray crystallography, biochemistry and biophysics. WDRs are protein-protein interaction hubs that are often found in key regulatory complexes involved in ribosomal biogenesis, epigenetic regulation, cell cycle control and DNA repair (see Schapira et al., 2017, https://doi.org/10.1038/nrd.2017.179), (Grebien et al, 2015, https://doi.org/10.1038/nchembio.1859) and (Getlik et al., 2016, DOI: 10.1021/acs.jmedchem.5b01630). Many WDR proteins are associated with diverse diseases, especially cancer, yet the majority of them are understudied. We have demonstrated the druggability of WDR proteins and seek to develop chemical biology tools to elucidate the function and therapeutic potential of select members of this family. This multidisciplinary project is in collaboration with several AI-based drug-discovery companies, academic labs as well as pharmaceutical companies. The successful candidate will have a broad knowledge of protein biochemistry and X-ray crystallography, a passion for scientific research as applied to drug discovery, and be eager to work as a team player in a fast-paced multidisciplinary environment.
Please forward your CV and contact information for 2-3 references to firstname.lastname@example.org with the subject line “WDR Postdoc”. Position will remain open until filled.