Applications are open for one postdoctoral position at the Institute of Science and Technology (IST) Austria to study the structure and function of intellectual-disability associated proteins and their involvement in chromatin modification.
The project is a collaboration between two groups at IST: the Bernecky group, which studies the structural basis of transcriptional and post-transcriptional gene regulation, and the Novarino group, which focuses on the genetic and molecular basis of neurodevelopmental disorders. The goal of the joint project will be to elucidate molecular mechanisms responsible for the development of autism and intellectual disability. The successful candidate will use biochemical, structural, and genomic techniques to investigate a frequently mutated protein and how it may link transcription and chromatin modification.
The ideal candidate will be a highly motivated scientist holding a Ph.D. in structural biology or biochemistry. Candidates should have experience in recombinant protein expression and purification of multi-subunit protein complexes. Experience in chromatin biology, nucleosome reconstitution, and/or cryo-electron microscopy is a plus.
Facilities include several transmission electron microscopes (TEMs) for negative stain and cryo-EM sample screening, including a FEI Tecnai 12 (120 kV) equipped with a CCD camera and a Thermo Fisher Glacios cryo-TEM (200 kV) equipped with a Falcon III direct electron detector. A 300-kV Thermo Fisher Titan Krios TEM equipped with state-of-the-art direct electron detectors (Falcon III, K3) is available for high-resolution data collection.
If you are interested, please send a cover letter CV, and references to Carrie Bernecky (carrie.bernecky@ist.ac.at) by 15 August 2020.
