The Structural Molecular Biology group led by Professor Guillermo Montoya works at the interface between biology, physics and chemistry, and uses molecular biology, X-ray crystallography and cryo-electron microscopy to dissect the working mechanisms of the macromolecules that constitute the cell’s machinery.
The Structural Molecular Biology group is seeking an excellent and highly motivated postdoctoral candidate to lead a project combining biochemistry, SPA cryoEM and crystallography to study protein-DNA complexes that allow the insertion of large DNA segments into a genome. The position is funded through an NNF distinguished investigator grant. The ideal candidate for this project will be a structural biologist with experience in protein-DNA biochemistry and cryo-EM and/or crystallography expertise. The position is funded for 3 years (2+1) with a possible extension for a 4th year.
The Novo Nordisk Foundation Center for Protein Research at the Faculty of Health and Medical Sciences (SUND), University of Copenhagen, performs basic and applied discovery research on human proteins of biomedical relevance. The Center comprises a wide range of expertise and resources, from in silico target identification, mass spectrometry based proteomics, structural biology, protein production and characterisation to elucidation of various disease mechanisms.
The Institute provides the state-of-the art infrastructure and instrumentation including a Titan Krios TEM equipped with the state-of-the-art direct electron detector and 3 auxiliary TEMs for sample characterisation. The Institute expects to incorporate another 200 Kv system with a Falcon III camera by the end of the year. In addition, the candidate will benefit from an intellectually stimulating, supportive and collaborative environment, including access to transferable skills workshops run by the Center and the University of Copenhagen (project writing courses, career development and leadership workshops), and a range of enabling core facilities in the Center including crystallisation, protein production, molecular biophysics, high performance computing, bioinformatics, and mass spectrometry.
For more information and to apply, click here.