Jobs in Structural Biology and Related Fields

Postdoctoral Position

Vrije Universiteit Brussels, Brussels, Belgium
Application deadline: 09 Feb 2014

Postdoctoral position in structure-function studies of G-protein networks in bacterial virulence and persistence Structural Biology Brussels (Vrije Universiteit Brussel/VIB) - Brussels, Belgium. 
At the Structural Biology Brussels laboratory (Vrije Universiteit Brussel/VIB), we are looking for a highly qualified and motivated postdoctoral researcher  with a strong  background  in   X-ray crystallography and  biophysics  and  interested  in biochemical and  structural studies  on enzymes  and G-protein networks involved  in bacterial  virulence and persistence. 
Project description: 
Guanine nucleotide binding  proteins (G-proteins  or GTPases) are central "regulatory hubs" in nearly all essential cellular processes. However, the mechanisms of intra- and intermolecular regulation of complex multi-domain GTPases and their involvement in human disease remain largely unexplored.  We aim to study the mechanism, regulation and  interaction  networks  of  important representatives of  these  complex GTPases,  in  the context  of  bacterial virulence  and  persistence. Through collaboration  with the  group of  Prof.  J. Michiels (Centre  of Microbial  and Plant  Genetics, KULeuven) we will combine the genetics and  biology of persistence and virulence with detailed biochemical, biophysical  and  structural  in  vitro studies,  in order to contribute to a complete mechanistic understanding of the underlying principles at  an atomic level. Different research topics in this field are currently being started  or ongoing in  our lab  and can  be discussed in more detail with the  interested/selected candidate.  

Required skills and experience: Ph.D. in the field of structural biology. Experience in protein expression, purification and characterization. Experience in protein crystallization and structure determination by X-ray crystallography. Knowledge in mechanistic enzymology and biophysical methods is an asset. Good communication and teamwork skills.

Send applications (including CV, research experience, and at least two names and contact information for references) to: