Jobs in Structural Biology and Related Fields

Postdoctoral Fellow - BRCA2 Complexes by EM

AstraZeneca, AstraZeneca Cambridge, United Kingdom
Application deadline: 31 Mar 2020

AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialisation of prescription medicines for some of the world’s most serious diseases. The company has a unique workplace culture that inspires innovation and collaboration. AstraZeneca believe in the potential of their people and you’ll develop beyond what you thought possible.

The new R&D Oncology organisation brings together early and late oncology teams, from discovery through to late-stage development, with oncology specific Regulatory and Biometrics groups.

You’ll be in a global pharmaceutical environment but also exposed to strong rigorous academic science. For example, every postdoc has an external academic mentor to ensure we are working and publishing at the highest level in a field. What’s more, you’ll have the support of a leading academic advisor, who’ll provide you with the guidance and knowledge you need to develop your career.

The Discovery Sciences team operates from truly state-of-the-art centres spanning the UK, US and Sweden. You’ll work with some of the most knowledgeable technological experts in the industry, all collaborating on high-profile drug discovery projects.

This is an opportunity for a talented and self-motivated scientist to undertake biophysical and structural studies of macromolecular complexes between BRCA2 and other tumour suppressor proteins. You’ll have access to state-of-the-art cryoEM and biophysics infrastructure with a leading structure and biophysics group and work in close collaboration with Prof Ashok Venkitaraman’s group at the MRC Cancer Unit.

For this role you’ll be expected to:

• Prepare and characterise protein complex samples

• Optimise cryo-EM data collection conditions

• Perform cryo-EM structure determination

• Integrate information from structural & biophysical studies to create structural models

• Present your results at scientific conferences and publish credible papers in peer reviewed journals

Education and Experience required:


• A PhD in Structural Biology or Biochemistry, supported by an understanding of protein structure and biochemistry

• Expertise in protein expression, purification and biochemical characterisation and in biophysical and structural techniques

• Experience in integrative structural biology


• Expertise in biophysical techniques for studying protein structure or molecular complexes, such as cryo-EM or X-ray crystallography

• Expertise in assembling/handling/characterising large protein-protein complexes

• Expertise in non-recombinant protein purification

Skills and Capabilities required:

• Excellent organisational, collaboration and communication skills

• Creativity and a drive for excellence, as demonstrated by a credible history of publication

This is a 3 year programme. 2 years will be a Fixed Term Contract, with a 1 year extension which will be merit based. The role will be based in Cambridge, UK, with a competitive salary on offer.

For more information and to apply for this role, head to the AstraZeneca website.

AstraZeneca Cambridge, United Kingdom

Postdoctoral Fellow - BRCA2 Complexes by EM