A PhD position is available in Mikhail Eltsov’s team at CBI/IGBMC to study the organization of the cell nucleus and mitotic chromosomes using correlative optical and electron microscopy, together with cellular cryo-electron tomography. The PhD student will use state-of-the-art techniques and participate in the further development of methods for in situ high-resolution structure determination.
Candidates should have a master’s degree in cell biology, biophysics or a related field. Experience in (cryo-)electron microscopy, image processing, optical microscopy, or hands-on histology skills would be an advantage. You will need good written and spoken English to effectively communicate, both in the team and with collaborators.
The CBI provides a leading-edge scientific and technological environment in integrated structural biology to address the structure and function of biological systems, notably on gene expression, from the atomic, molecular to the tissue scales. The CBI, hosts the French and European Infrastructures for Integrated Structural Biology, FRISBI and Instruct which comprises advanced electron microscopy facilities equipped with cutting-edge instrumentation such as Titan Krios and Polara cryo electron microscopes, cryo Focused Ion Beam Scanning Electron Microscope (FIB/SEM) and super-resolution fluorescence microscopy. The Titan Krios microscope is equipped with Cs corrector, Falcon 3 camera, GIF energy filter, K3 camera and phase plate. In addition, the EM facility has a suite of associated equipments for sample preparation and dedicated computing resources for image processing and 3D reconstruction by single particle cryo-EM and cryo electron tomography (cryo-ET).
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