Jobs in Structural Biology and Related Fields

PhD Position in Structure Biology

Department of chemistry, Umeå University, Umea, Sweden

Application deadline: 10 Dec 2020

A doctoral position in structural biology: development of drugs to block bacterial virulence factors is available in Professor Elisabeth Sauer-Eriksson's laboratory at the Department of Chemistry, Umeå University.

Working tasks
The aim of the project is to describe factors that govern the PrfA regulation in listeria and to develop inhibitors of PrfA through drug design based on structural studies. The expected tasks are summarized below:

• Purification of PrfA from listeria according to established protocol. Cloning, expression and purification of PrfA-like transcription factors from other bacteria.
• Structural studies on PrfA from listeria in various biologically relevant conditions or in complexes with designed inhibitors.
• Structural biological analysis of native and inhibited PrfA from other pathogenic bacteria.
• Biochemical and biophysical analysis of protein and protein complexes with, for example, light spectroscopy and calorimetric methods.
• Writing of scientific articles.

Qualifications
To be admitted for studies at third-cycle level you are required to have completed a second-cycle level degree, or completed course requirements of at least 240 ECTS credits, of which at least 60 ECTS credits are at second-cycle level or have an equivalent education from abroad, or equivalent qualifications.

To fulfil the specific entry requirements to be admitted for studies at third-cycle level in chemistry, you are required to have completed first-cycle courses of at least 90 ECTS credits within the field of chemistry or another subject considered to be directly relevant to the specialization in question. Of those 90 ECTS credits, at least 15 ECTS credits shall have been acquired at second-cycle level within the specialization or an equivalent subject.

Good knowledge in English, both written and spoken, is a requirement. You must be strongly self-motivated and have the ability to work in a multidisciplinary work environment.

Application
A complete application should contain the following documents:

• A cover letter including a description of your research interests and motivation for applying
• A Curriculum Vitae
• Certified copies of degree certificates or equivalent, including documentation of completed academic courses and obtained grades and other relevant certificates
• Name and contact information of at least two reference persons

Applications must be submitted via our e-recruitment system no later than December 10 2020.