Instruct Centre UK - OPIC


Oxford Particle Imaging Centre specialises in cryogenic electron microscopy


Oxford Particle Imaging Centre (OPIC) houses state-of-the art equipment for cryogenic electron microscopy (cryo-EM). This includes a Titan Krios and a Glacios instrument, both fitted with direct electron detectors, in addition to auxiliary equipment for sample preparation.



OPIC facilities enable imaging of macromolecular complexes (including membrane proteins, enzymes, and viruses), organelles, and cells in their native state. Through computational reconstruction of cryo-EM images it is possible to derive three-dimensional density maps of biological structures. Often these maps have sufficient resolution to allow building of atomic models leading to mechanistic understanding of cellular functions.


 

The local groups using OPIC facilities represent a wide range of research ranging from cell surface receptors and ion-channels to viral polymerases and entire viral particles. Central to OPIC are biosafety containment laboratories which facilitate the study of infectious viruses relevant to human and animal health. OPIC welcomes research proposals from a broad science base.

OPIC

Wellcome Centre for Human Genetics, Roosevelt Drive

OX3 7BN, Oxford

United Kingdom

www.opic.ox.ac.uk

Visitor information

Oxford Particle Imaging Centre (OPIC) is part of the Division of Structural Biology within the Nuffield Department of Medicine at the University of Oxford. OPIC facilities are located in the Wellcome Centre for Human Genetics on Old Road Campus.

For more information on travel to the institute click here:

http://www.opic.ox.ac.uk/contact

Flagship Service/Technology at OPIC:

Glacios and Titan Krios instruments are available for cryo-EM

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View All Electron Microscopy at Instruct

Scientific Contacts
Juha Huiskonen
Juha Huiskonen

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David Stuart
David Stuart

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Admin Contacts
Melissa Matthews
Melissa Matthews

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Technical Contacts
Robin Parsons
Robin Parsons

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Dimple Karia
Dimple Karia

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Beth MacLean
Beth MacLean

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Publications

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