Service / Technology Type

Multi Angle / Dynamic Light Scattering (MALS)

Detailed biophysical characterization of biomolecules in solution

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Details

The availability in Instruct of the most advanced instruments for Multi Angle Dynamic Light Scattering (MALS) combined quasi-elastic light scattering (QELS) detectors allows the user to carry out a detailed biophysical characterization of biomolecules in solution. The measure of the intensity of laser light, scattered at different angles by macromolecules passing through the flow cell and the analysis of the autocorrelation function of the laser light fluctuations allow the calculation of: the concentration of the biomolecules in solution, the molecular weight, the radius of gyration (rg), the translational diffusion coefficient (Dt) and the related hydrodynamic radius (rh). The technique is extremely sensitive and provides information on the shape and aggregation state of the biomolecules in solution.

Service/Technology Instances

Multi Angle / Dynamic Light Scattering (MALS)

Multi Angle / Dynamic Light Scattering (MALS) Experts

Lucia Banci
Lucia Banci
CERM/CIRMMP
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Isabelle Billas
Isabelle Billas
IGBMC-CERBM
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Christine Ebel
Christine Ebel
Institut de Biologie Structurale
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Anastassis Perrakis
Anastassis Perrakis
The Netherlands Cancer Institute
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