Service / Technology

Multi Angle / Dynamic Light Scattering (MALS)

Detailed biophysical characterization of biomolecules in solution

Details

The availability in Instruct of the most advanced instruments for Multi Angle Dynamic Light Scattering (MALS) combined quasi-elastic light scattering (QELS) detectors allows the user to carry out a detailed biophysical characterization of biomolecules in solution. The measure of the intensity of laser light, scattered at different angles by macromolecules passing through the flow cell and the analysis of the autocorrelation function of the laser light fluctuations allow the calculation of: the concentration of the biomolecules in solution, the molecular weight, the radius of gyration (rg), the translational diffusion coefficient (Dt) and the related hydrodynamic radius (rh). The technique is extremely sensitive and provides information on the shape and aggregation state of the biomolecules in solution.

Service/Technology Instances

Lucia Banci email hidden
Isabelle Billas email hidden
Christine Ebel email hidden
Anastassis Perrakis email hidden

Instruct has 4 centres offering Multi Angle / Dynamic Light Scattering (MALS) across Europe.

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