Crystal Form Discovery Details

User Guide

Having a construct that is already known to crystallize is a prerequisite for attempting this approach.

Technical Specifications

The best approach to try depends on the target protein and question being studied:

  1. for biochemically well-behaved proteins, surface mutations are most convenient
  2. for proteins with poor expression, varying the expression system is typically powerful
  3. for proteins that crystallize sporadically, adding ligands can help stabilise conformations

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